node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTN2 | CASQ2 | ENSGALP00000054549 | ENSGALP00000036165 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | 0.684 |
ACTN2 | ENSGALP00000045329 | ENSGALP00000054549 | ENSGALP00000045329 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Asp-B-Hydro_N domain-containing protein. | 0.463 |
ACTN2 | MYL10 | ENSGALP00000054549 | ENSGALP00000051468 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Myosin regulatory light chain 2B, cardiac muscle isoform. | 0.583 |
ACTN2 | MYL2 | ENSGALP00000054549 | ENSGALP00000034439 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Myosin regulatory light chain 2A, cardiac muscle isoform. | 0.801 |
ACTN2 | RYR2 | ENSGALP00000054549 | ENSGALP00000049908 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Ryanodine receptor 2. | 0.556 |
ACTN2 | SRL | ENSGALP00000054549 | ENSGALP00000053831 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Sarcalumenin; May be involved in the regulation of calcium transport. | 0.549 |
ACTN2 | TNNI2 | ENSGALP00000054549 | ENSGALP00000010627 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.837 |
ACTN2 | TNNT3 | ENSGALP00000054549 | ENSGALP00000063676 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | Troponin T, fast skeletal muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.861 |
ASPH-2 | CASQ2 | ENSGALP00000044812 | ENSGALP00000036165 | Asp-B-Hydro_N domain-containing protein. | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | 0.932 |
ASPH-2 | ENSGALP00000045329 | ENSGALP00000044812 | ENSGALP00000045329 | Asp-B-Hydro_N domain-containing protein. | Asp-B-Hydro_N domain-containing protein. | 0.479 |
ASPH-2 | RYR2 | ENSGALP00000044812 | ENSGALP00000049908 | Asp-B-Hydro_N domain-containing protein. | Ryanodine receptor 2. | 0.851 |
ASPH-2 | RYR3 | ENSGALP00000044812 | ENSGALP00000050499 | Asp-B-Hydro_N domain-containing protein. | Uncharacterized protein. | 0.820 |
CASQ2 | ACTN2 | ENSGALP00000036165 | ENSGALP00000054549 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). | 0.684 |
CASQ2 | ASPH-2 | ENSGALP00000036165 | ENSGALP00000044812 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | Asp-B-Hydro_N domain-containing protein. | 0.932 |
CASQ2 | ENSGALP00000045329 | ENSGALP00000036165 | ENSGALP00000045329 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | Asp-B-Hydro_N domain-containing protein. | 0.684 |
CASQ2 | MYL10 | ENSGALP00000036165 | ENSGALP00000051468 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | Myosin regulatory light chain 2B, cardiac muscle isoform. | 0.744 |
CASQ2 | MYL2 | ENSGALP00000036165 | ENSGALP00000034439 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | Myosin regulatory light chain 2A, cardiac muscle isoform. | 0.776 |
CASQ2 | RYR2 | ENSGALP00000036165 | ENSGALP00000049908 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | Ryanodine receptor 2. | 0.975 |
CASQ2 | RYR3 | ENSGALP00000036165 | ENSGALP00000050499 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | Uncharacterized protein. | 0.947 |
CASQ2 | SRL | ENSGALP00000036165 | ENSGALP00000053831 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. | Sarcalumenin; May be involved in the regulation of calcium transport. | 0.712 |