STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DCXRD-erythrulose reductase; Catalyzes the reduction of D-erythrulose to D-threitol with the concomitant oxidation of NAD(P)H to NAD(P)(+). NADH is less effective than NADPH. May also catalyze the reduction of L-xylulose; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)    
Predicted Functional Partners:
SORD
Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with D- sorbitol (D-glucitol) as substrate, leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity).
   
 
 0.914
LOC418170
Aldo_ket_red domain-containing protein.
   
 
 0.911
LOC425137
Aldo_ket_red domain-containing protein.
     
 0.906
AKR1B1
Aldo_ket_red domain-containing protein.
     
 0.906
AKR1B10
Aldo-keto reductase.
     
 0.906
AKR1E2
Aldo_ket_red domain-containing protein.
     
 0.906
ANKRD10
Ankyrin repeat domain-containing protein 10.
    
 
 0.843
LOC100857714
Uncharacterized protein.
      
 0.842
SNX25
Sorting nexin 25.
      
 0.782
PMS1
HMG box domain-containing protein.
      
 0.761
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.