STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HMGCS1Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (542 aa)    
Predicted Functional Partners:
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
  
 
 0.999
FDPS
Farnesyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate; Belongs to the FPP/GGPP synthase family.
  
 
 0.996
ACAT2
Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.990
ACAA1
Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.986
ACAT1
Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.986
ACAA2
Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.986
SQLE
SE domain-containing protein.
   
  
 0.983
CYP51A1
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
 
 0.982
HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
   
 
 0.975
IDI2
Nudix hydrolase domain-containing protein.
  
  
 0.974
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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