node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPRIN1 | G3BP1 | ENSGALP00000021996 | ENSGALP00000006604 | Cytoplasmic activation-proliferation-associated protein 1. | Uncharacterized protein. | 0.995 |
CAPRIN1 | G3BP2 | ENSGALP00000021996 | ENSGALP00000017667 | Cytoplasmic activation-proliferation-associated protein 1. | G3BP stress granule assembly factor 2. | 0.956 |
CAPRIN1 | UBAP2L | ENSGALP00000021996 | ENSGALP00000057127 | Cytoplasmic activation-proliferation-associated protein 1. | Ubiquitin associated protein 2 like. | 0.616 |
CAPRIN1 | USP10 | ENSGALP00000021996 | ENSGALP00000056499 | Cytoplasmic activation-proliferation-associated protein 1. | Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity). | 0.792 |
CFTR | LOC101747587 | ENSGALP00000050160 | ENSGALP00000053353 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] | 0.430 |
CFTR | SNX3 | ENSGALP00000050160 | ENSGALP00000024654 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | PX domain-containing protein. | 0.406 |
CFTR | USP10 | ENSGALP00000050160 | ENSGALP00000056499 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity). | 0.820 |
G3BP1 | CAPRIN1 | ENSGALP00000006604 | ENSGALP00000021996 | Uncharacterized protein. | Cytoplasmic activation-proliferation-associated protein 1. | 0.995 |
G3BP1 | G3BP2 | ENSGALP00000006604 | ENSGALP00000017667 | Uncharacterized protein. | G3BP stress granule assembly factor 2. | 0.828 |
G3BP1 | TRNAU1AP | ENSGALP00000006604 | ENSGALP00000001992 | Uncharacterized protein. | tRNA selenocysteine 1 associated protein 1. | 0.625 |
G3BP1 | UBAP2L | ENSGALP00000006604 | ENSGALP00000057127 | Uncharacterized protein. | Ubiquitin associated protein 2 like. | 0.826 |
G3BP1 | USP10 | ENSGALP00000006604 | ENSGALP00000056499 | Uncharacterized protein. | Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity). | 0.970 |
G3BP2 | CAPRIN1 | ENSGALP00000017667 | ENSGALP00000021996 | G3BP stress granule assembly factor 2. | Cytoplasmic activation-proliferation-associated protein 1. | 0.956 |
G3BP2 | G3BP1 | ENSGALP00000017667 | ENSGALP00000006604 | G3BP stress granule assembly factor 2. | Uncharacterized protein. | 0.828 |
G3BP2 | TRNAU1AP | ENSGALP00000017667 | ENSGALP00000001992 | G3BP stress granule assembly factor 2. | tRNA selenocysteine 1 associated protein 1. | 0.625 |
G3BP2 | UBAP2L | ENSGALP00000017667 | ENSGALP00000057127 | G3BP stress granule assembly factor 2. | Ubiquitin associated protein 2 like. | 0.848 |
G3BP2 | USP10 | ENSGALP00000017667 | ENSGALP00000056499 | G3BP stress granule assembly factor 2. | Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity). | 0.945 |
LOC101747587 | CFTR | ENSGALP00000053353 | ENSGALP00000050160 | Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. | 0.430 |
LOC101747587 | USP10 | ENSGALP00000053353 | ENSGALP00000056499 | Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] | Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity). | 0.674 |
LOC101747587 | USP13 | ENSGALP00000053353 | ENSGALP00000014471 | Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] | Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). | 0.816 |