STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH2Uncharacterized protein. (2432 aa)    
Predicted Functional Partners:
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.989
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
   
 0.988
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.984
JAG2
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.984
PSEN1
Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.
    
 0.942
RBPJL
Recombination signal binding protein for immunoglobulin kappa J region like.
    
 0.938
MFNG
Beta-1,3-N-acetylglucosaminyltransferase.
   
 0.938
LFNG
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning.
   
 0.937
ADAM17
Tumor necrosis factor alpha converting enzyme.
    
 0.935
NOTCH1
Uncharacterized protein.
  
0.933
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.