node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F1NA05_CHICK | RANGAP1 | ENSGALP00000035780 | ENSGALP00000019492 | Uncharacterized protein. | RanGAP1_C domain-containing protein. | 0.988 |
F1NA05_CHICK | SUMO1 | ENSGALP00000035780 | ENSGALP00000069231 | Uncharacterized protein. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.966 |
F1NA05_CHICK | SUMO2 | ENSGALP00000035780 | ENSGALP00000012928 | Uncharacterized protein. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | 0.966 |
F1NA05_CHICK | SUMO3 | ENSGALP00000035780 | ENSGALP00000047262 | Uncharacterized protein. | Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I (By similarity). | 0.966 |
F1NA05_CHICK | UBE2I | ENSGALP00000035780 | ENSGALP00000010363 | Uncharacterized protein. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family. | 0.960 |
PIAS1 | RANGAP1 | ENSGALP00000012927 | ENSGALP00000019492 | Uncharacterized protein. | RanGAP1_C domain-containing protein. | 0.423 |
PIAS1 | SAE1 | ENSGALP00000012927 | ENSGALP00000070956 | Uncharacterized protein. | SUMO1 activating enzyme subunit 1. | 0.900 |
PIAS1 | SUMO1 | ENSGALP00000012927 | ENSGALP00000069231 | Uncharacterized protein. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.993 |
PIAS1 | SUMO2 | ENSGALP00000012927 | ENSGALP00000012928 | Uncharacterized protein. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | 0.942 |
PIAS1 | SUMO3 | ENSGALP00000012927 | ENSGALP00000047262 | Uncharacterized protein. | Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I (By similarity). | 0.896 |
PIAS1 | UBA2 | ENSGALP00000012927 | ENSGALP00000008003 | Uncharacterized protein. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.731 |
PIAS1 | UBE2I | ENSGALP00000012927 | ENSGALP00000010363 | Uncharacterized protein. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family. | 0.971 |
PIAS3 | RANGAP1 | ENSGALP00000044365 | ENSGALP00000019492 | Protein inhibitor of activated STAT 3. | RanGAP1_C domain-containing protein. | 0.427 |
PIAS3 | SAE1 | ENSGALP00000044365 | ENSGALP00000070956 | Protein inhibitor of activated STAT 3. | SUMO1 activating enzyme subunit 1. | 0.788 |
PIAS3 | SUMO1 | ENSGALP00000044365 | ENSGALP00000069231 | Protein inhibitor of activated STAT 3. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] | 0.963 |
PIAS3 | SUMO2 | ENSGALP00000044365 | ENSGALP00000012928 | Protein inhibitor of activated STAT 3. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are al [...] | 0.907 |
PIAS3 | SUMO3 | ENSGALP00000044365 | ENSGALP00000047262 | Protein inhibitor of activated STAT 3. | Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I (By similarity). | 0.871 |
PIAS3 | UBA2 | ENSGALP00000044365 | ENSGALP00000008003 | Protein inhibitor of activated STAT 3. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.663 |
PIAS3 | UBE2I | ENSGALP00000044365 | ENSGALP00000010363 | Protein inhibitor of activated STAT 3. | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation; Belongs to the ubiquitin-conjugating enzyme family. | 0.954 |
RANGAP1 | F1NA05_CHICK | ENSGALP00000019492 | ENSGALP00000035780 | RanGAP1_C domain-containing protein. | Uncharacterized protein. | 0.988 |