STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (359 aa)    
Predicted Functional Partners:
AGT
Angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Belongs to the serpin family
   
 0.989
GNA11
Guanine nucleotide-binding protein subunit alpha-11; Gallus gallus guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11), mRNA
    
 0.964
GNAQ
Guanine nucleotide-binding protein g(q) subunit alpha; G protein subunit alpha q; Gallus gallus guanine nucleotide binding protein (G protein), q polypeptide (GNAQ), mRNA
    
 0.964
REN
Renin isoform x5; Renin; Belongs to the peptidase A1 family
   
  
 0.924
ACE
Angiotensin-converting enzyme precursor; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin
   
  
 0.914
ACE2
Angiotensin-converting enzyme 2; Angiotensin I converting enzyme 2
   
  
 0.847
GNA12
Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide binding protein (G protein) alpha 12
    
 0.845
GNA13
Guanine nucleotide-binding protein subunit alpha-13; G protein subunit alpha 13; Guanine nucleotide binding protein (G protein), alpha 13
    
  0.843
SAG
S-antigen visual arrestin; S-antigen; retina and pineal gland (arrestin)
    
 0.839
AGTR2
Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family
   
 
0.824
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.