node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHFR | ENSGALP00000071758 | ENSGALP00000041459 | ENSGALP00000071758 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Thymidylat_synt domain-containing protein. | 0.986 |
DHFR | FPGS | ENSGALP00000041459 | ENSGALP00000047333 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Folylpolyglutamate synthase. | 0.998 |
DHFR | GART | ENSGALP00000041459 | ENSGALP00000049365 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Trifunctional purine biosynthetic protein adenosine-3; In the central section; belongs to the AIR synthase family. | 0.975 |
DHFR | GART-B | ENSGALP00000041459 | ENSGALP00000043823 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.975 |
DHFR | MTFMT | ENSGALP00000041459 | ENSGALP00000043481 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Mitochondrial methionyl-tRNA formyltransferase. | 0.979 |
DHFR | MTHFD1 | ENSGALP00000041459 | ENSGALP00000019224 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Uncharacterized protein. | 0.985 |
DHFR | MTHFD1L | ENSGALP00000041459 | ENSGALP00000020258 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. | 0.980 |
DHFR | MTR | ENSGALP00000041459 | ENSGALP00000017592 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Uncharacterized protein. | 0.975 |
DHFR | SHMT1 | ENSGALP00000041459 | ENSGALP00000047253 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.996 |
DHFR | TYMS | ENSGALP00000041459 | ENSGALP00000060462 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | Thymidylat_synt domain-containing protein. | 0.999 |
ENSGALP00000071758 | DHFR | ENSGALP00000071758 | ENSGALP00000041459 | Thymidylat_synt domain-containing protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | 0.986 |
ENSGALP00000071758 | FPGS | ENSGALP00000071758 | ENSGALP00000047333 | Thymidylat_synt domain-containing protein. | Folylpolyglutamate synthase. | 0.907 |
ENSGALP00000071758 | GART | ENSGALP00000071758 | ENSGALP00000049365 | Thymidylat_synt domain-containing protein. | Trifunctional purine biosynthetic protein adenosine-3; In the central section; belongs to the AIR synthase family. | 0.651 |
ENSGALP00000071758 | GART-B | ENSGALP00000071758 | ENSGALP00000043823 | Thymidylat_synt domain-containing protein. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.651 |
ENSGALP00000071758 | MTFMT | ENSGALP00000071758 | ENSGALP00000043481 | Thymidylat_synt domain-containing protein. | Mitochondrial methionyl-tRNA formyltransferase. | 0.673 |
ENSGALP00000071758 | MTHFD1 | ENSGALP00000071758 | ENSGALP00000019224 | Thymidylat_synt domain-containing protein. | Uncharacterized protein. | 0.473 |
ENSGALP00000071758 | MTHFD1L | ENSGALP00000071758 | ENSGALP00000020258 | Thymidylat_synt domain-containing protein. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. | 0.473 |
ENSGALP00000071758 | SHMT1 | ENSGALP00000071758 | ENSGALP00000047253 | Thymidylat_synt domain-containing protein. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.704 |
ENSGALP00000071758 | TYMS | ENSGALP00000071758 | ENSGALP00000060462 | Thymidylat_synt domain-containing protein. | Thymidylat_synt domain-containing protein. | 0.936 |
FPGS | DHFR | ENSGALP00000047333 | ENSGALP00000041459 | Folylpolyglutamate synthase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA. | 0.998 |