node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGF | FGF7 | ENSGALP00000044972 | ENSGALP00000042868 | Uncharacterized protein. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.957 |
EGF | FGFR1 | ENSGALP00000044972 | ENSGALP00000046610 | Uncharacterized protein. | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers re [...] | 0.862 |
EGF | FGFR2 | ENSGALP00000044972 | ENSGALP00000045192 | Uncharacterized protein. | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.818 |
EGF | FGFR3 | ENSGALP00000044972 | ENSGALP00000001710 | Uncharacterized protein. | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] | 0.816 |
EGF | FGFR4 | ENSGALP00000044972 | ENSGALP00000025286 | Uncharacterized protein. | Fibroblast growth factor receptor. | 0.782 |
EGF | FLT1 | ENSGALP00000044972 | ENSGALP00000027556 | Uncharacterized protein. | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the c [...] | 0.850 |
EGF | HGF | ENSGALP00000044972 | ENSGALP00000049829 | Uncharacterized protein. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.985 |
EGF | KDR | ENSGALP00000044972 | ENSGALP00000022522 | Uncharacterized protein. | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.885 |
EGF | PDGFRA | ENSGALP00000044972 | ENSGALP00000064586 | Uncharacterized protein. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound he [...] | 0.974 |
EGF | SHH | ENSGALP00000044972 | ENSGALP00000010292 | Uncharacterized protein. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.745 |
FGF7 | EGF | ENSGALP00000042868 | ENSGALP00000044972 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Uncharacterized protein. | 0.957 |
FGF7 | FGFR1 | ENSGALP00000042868 | ENSGALP00000046610 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers re [...] | 0.971 |
FGF7 | FGFR2 | ENSGALP00000042868 | ENSGALP00000045192 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] | 0.993 |
FGF7 | FGFR3 | ENSGALP00000042868 | ENSGALP00000001710 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] | 0.970 |
FGF7 | FGFR4 | ENSGALP00000042868 | ENSGALP00000025286 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.974 |
FGF7 | FLT1 | ENSGALP00000042868 | ENSGALP00000027556 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the c [...] | 0.869 |
FGF7 | HGF | ENSGALP00000042868 | ENSGALP00000049829 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.878 |
FGF7 | KDR | ENSGALP00000042868 | ENSGALP00000022522 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.901 |
FGF7 | PDGFRA | ENSGALP00000042868 | ENSGALP00000064586 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound he [...] | 0.911 |
FGF7 | SHH | ENSGALP00000042868 | ENSGALP00000010292 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.875 |