STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE16563.1Hexokinase; COGs: COG5026 Hexokinase; InterPro IPR001312; KEGG: tpp:TPASS_0505 hexokinase; PFAM: Hexokinase; PRIAM: Hexokinase; SPTR: Hexokinase; IMG reference gene:2504920022; PFAM: Hexokinase. (444 aa)    
Predicted Functional Partners:
pgi
COGs: COG0166 Glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); InterPro IPR001672; KEGG: eel:EUBELI_00049 glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase (PGI); SPTR: Glucose-6-phosphate isomerase; IMG reference gene:2504920733; PFAM: Phosphoglucose isomerase; Belongs to the GPI family.
   
 
 0.950
AEE17360.1
Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844; KEGG: tde:TDE0864 phosphohexose mutase family protein; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; SPTR: Phosphohexose mutase family protein; IMG reference gene:2504920857; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I.
  
 
 0.949
AEE17015.1
Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterPro IPR005844:IPR005845; KEGG: tde:TDE1998 phosphohexose mutase family protein; PFAM: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I; Alpha-D-phosphohexomutase, alpha/beta/alpha domain II; SPTR: Phosphoglucomutase; IMG reference gene:2504920499; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase [...]
   
 
 0.925
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
   
 
 0.924
pfp
Diphosphate/fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
   
 
 0.924
pfp-2
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
   
 
 0.924
pfkA-2
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
   
 
 0.924
nagB
Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
   
 
 0.922
AEE17308.1
COGs: COG1482 Phosphomannose isomerase; InterPro IPR001250; KEGG: mannose-6-phosphate isomerase, class I; PFAM: Mannose-6-phosphate isomerase, type I; PRIAM: Mannose-6-phosphate isomerase; SPTR: Phosphomannose isomerase type I; IMG reference gene:2504920804; PFAM: Phosphomannose isomerase type I.
    
 0.920
glmS
Glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
   
 
 0.919
Your Current Organism:
Treponema brennaborense
NCBI taxonomy Id: 906968
Other names: T. brennaborense DSM 12168, Treponema brennaborense DSM 12168, Treponema brennaborense str. DSM 12168, Treponema brennaborense strain DSM 12168
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