STRINGSTRING
ileS protein (Ewingella americana) - STRING interaction network
"ileS" - Isoleucine--tRNA ligase in Ewingella americana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ileSIsoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile) (938 aa)    
Predicted Functional Partners:
lspA
Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family (168 aa)
   
  0.987
pheT
Phenylalanine--tRNA ligase beta subunit; Protein involved in tRNA binding, RNA binding, ATP binding, magnesium ion binding, phenylalanine-tRNA ligase activity, nucleotide binding, phenylalanyl-tRNA aminoacylation and tRNA processing; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily (795 aa)
   
 
  0.967
GEAM_0228
Peptidyl-prolyl cis-trans isomerase; Protein involved in protein folding (156 aa)
 
      0.962
leuS
Leucine--tRNA ligase; Protein involved in ATP binding, nucleotide binding, aminoacyl-tRNA ligase activity, aminoacyl-tRNA editing activity, leucine-tRNA ligase activity, leucyl-tRNA aminoacylation and tRNA aminoacylation for protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family (860 aa)
 
0.951
ribF
Protein involved in riboflavin kinase activity, FMN adenylyltransferase activity, FAD biosynthetic process, riboflavin biosynthetic process and FMN biosynthetic process; Belongs to the ribF family (312 aa)
 
   
  0.949
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction- proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as ’pretransfer’ editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated ’posttransfer’ editing and involves deacy [...] (572 aa)
   
  0.943
lysS
Lysine--tRNA ligase; Protein involved in nucleic acid binding, ATP binding, nucleotide binding, aminoacyl-tRNA ligase activity, lysine-tRNA ligase activity, lysyl-tRNA aminoacylation and tRNA aminoacylation for protein translation; Belongs to the class-II aminoacyl-tRNA synthetase family (514 aa)
   
  0.935
alaS
Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family (875 aa)
 
 
  0.921
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (618 aa)
   
  0.897
ispH
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis (317 aa)
   
   
  0.895
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
Server load: low (12%) [HD]