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GEAM_0264 protein (Ewingella americana) - STRING interaction network
"GEAM_0264" - Protein involved in acetolactate synthase activity, isoleucine biosynthetic process, valine biosynthetic process and branched-chain amino acid biosynthetic process in Ewingella americana
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Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GEAM_0264Protein involved in acetolactate synthase activity, isoleucine biosynthetic process, valine biosynthetic process and branched-chain amino acid biosynthetic process (163 aa)    
Predicted Functional Partners:
ilvI
Acetolactate synthase; Protein involved in thiamine pyrophosphate binding, catalytic activity, magnesium ion binding, acetolactate synthase activity, flavin adenine dinucleotide binding, isoleucine biosynthetic process, valine biosynthetic process and branched-chain amino acid biosynthetic process (516 aa)
  0.997
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (491 aa)
 
  0.970
ilvG
Acetolactate synthase; Protein involved in magnesium ion binding, thiamine pyrophosphate binding, catalytic activity, acetolactate synthase activity, flavin adenine dinucleotide binding, isoleucine biosynthetic process, valine biosynthetic process and branched-chain amino acid biosynthetic process (548 aa)
  0.961
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (365 aa)
 
 
  0.953
GEAM_0468
Protein involved in prephenate dehydratase activity, chorismate mutase activity, chorismate metabolic process and L-phenylalanine biosynthetic process (385 aa)
 
 
  0.944
ilvD
Dihydroxy-acid dehydratase; Protein involved in catalytic activity, dihydroxy-acid dehydratase activity, isoleucine biosynthetic process, valine biosynthetic process, metabolic process and branched-chain amino acid biosynthetic process; Belongs to the IlvD/Edd family (616 aa)
 
  0.938
GEAM_3110
Thiamine pyrophosphate-requiring enzyme; COG0028; Protein involved in thiamine pyrophosphate binding and catalytic activity (534 aa)
 
  0.920
alsS
Acetolactate synthase, catabolic; Protein involved in magnesium ion binding, thiamine pyrophosphate binding, catalytic activity, acetolactate synthase activity, fermentation, acetoin biosynthetic process and butanediol metabolic process; Belongs to the TPP enzyme family (558 aa)
 
  0.916
GEAM_1000
Thiamine pyrophosphate enzyme; Protein involved in magnesium ion binding, thiamine pyrophosphate binding and catalytic activity; Belongs to the TPP enzyme family (573 aa)
 
  0.908
ilvA
L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (514 aa)
 
 
  0.903
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
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