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hpt protein (Ewingella americana) - STRING interaction network
"hpt" - Protein involved in hypoxanthine phosphoribosyltransferase activity, purine ribonucleoside salvage and nucleoside metabolic process in Ewingella americana
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hptProtein involved in hypoxanthine phosphoribosyltransferase activity, purine ribonucleoside salvage and nucleoside metabolic process; Belongs to the purine/pyrimidine phosphoribosyltransferase family (178 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (525 aa)
   
 
  0.963
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (440 aa)
   
 
  0.906
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (432 aa)
   
 
  0.904
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (183 aa)
   
  0.887
gpt
Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily (152 aa)
   
 
  0.880
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP (207 aa)
   
   
  0.870
udp
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family (253 aa)
     
 
  0.868
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family (214 aa)
 
 
  0.860
purH
Bifunctional purine biosynthesis protein PurH; Protein involved in IMP cyclohydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, catalytic activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process (529 aa)
   
 
  0.832
add
Protein involved in deaminase activity, purine-containing compound salvage and purine ribonucleoside monophosphate biosynthetic process (332 aa)
   
 
  0.829
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
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