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panB protein (Ewingella americana) - STRING interaction network
"panB" - 3-methyl-2-oxobutanoate hydroxymethyltransferase in Ewingella americana
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate; Belongs to the PanB family (264 aa)    
Predicted Functional Partners:
panC
Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate; Belongs to the pantothenate synthetase family (284 aa)
 
  0.999
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (122 aa)
 
   
  0.981
panE
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (304 aa)
   
  0.968
folK
Protein involved in 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity and folic acid-containing compound biosynthetic process (159 aa)
   
  0.938
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (491 aa)
       
  0.888
ilvD
Dihydroxy-acid dehydratase; Protein involved in catalytic activity, dihydroxy-acid dehydratase activity, isoleucine biosynthetic process, valine biosynthetic process, metabolic process and branched-chain amino acid biosynthetic process; Belongs to the IlvD/Edd family (616 aa)
     
 
  0.831
GEAM_1335
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (298 aa)
       
  0.813
ilvE
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family (309 aa)
       
  0.802
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (525 aa)
         
  0.788
birA
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5’-adenylate (BirA-bio- 5’-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (319 aa)
         
  0.767
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
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