STRINGSTRING
mrcB protein (Ewingella americana) - STRING interaction network
"mrcB" - Penicillin-binding protein 1B in Ewingella americana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mrcBPenicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (863 aa)    
Predicted Functional Partners:
GEAM_0269
Peptidoglycan D,D-transpeptidase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily (587 aa)
 
  0.972
mrdA
Peptidoglycan D,D-transpeptidase MrdA; Catalyzes cross-linking of the peptidoglycan cell wall (634 aa)
 
  0.939
GEAM_0631
Peptidoglycan D,D-transpeptidase MrdA; Catalyzes cross-linking of the peptidoglycan cell wall; Belongs to the transpeptidase family. MrdA subfamily (649 aa)
 
  0.935
GEAM_2199
YcfM family salvage pathway lipoprotein; Overlaps another CDS with the same product name (122 aa)
   
 
  0.927
GEAM_3425
Multimodular transpeptidase-transglycosylase; Protein involved in catalytic activity, penicillin binding, transferase activity, transferring pentosyl groups, peptidase activity, peptidoglycan biosynthetic process, peptidoglycan-based cell wall biogenesis and response to antibiotic (836 aa)
   
 
0.894
murG
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily (355 aa)
 
 
  0.850
GEAM_2360
Peptidoglycan D,D-transpeptidase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (561 aa)
 
  0.817
ftsW
Probable peptidoglycan glycosyltransferase FtsW; Peptidoglycan polymerase that is essential for cell division; Belongs to the SEDS family. FtsW subfamily (400 aa)
 
  0.797
dacB
Protein involved in serine-type carboxypeptidase activity, peptidoglycan biosynthetic process and proteolysis (477 aa)
     
 
  0.794
pbpC
Multimodular transpeptidase-transglycosylase; Protein involved in catalytic activity, penicillin binding, peptidoglycan glycosyltransferase activity, peptidoglycan biosynthetic process and peptidoglycan-based cell wall biogenesis (770 aa)
   
   
0.792
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
Server load: low (11%) [HD]