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hemL protein (Ewingella americana) - STRING interaction network
"hemL" - Glutamate-1-semialdehyde 2,1-aminomutase in Ewingella americana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hemLGlutamate-1-semialdehyde 2,1-aminomutase; Protein involved in pyridoxal phosphate binding, transaminase activity, glutamate-1-semialdehyde 2,1-aminomutase activity, porphyrin-containing compound biosynthetic process and tetrapyrrole biosynthetic process (426 aa)    
Predicted Functional Partners:
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA); Belongs to the glutamyl-tRNA reductase family (420 aa)
 
  0.989
GEAM_1112
Delta-aminolevulinic acid dehydratase; Protein involved in porphobilinogen synthase activity, metal ion binding and tetrapyrrole biosynthetic process; Belongs to the ALAD family (324 aa)
 
 
  0.982
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps; Belongs to the HMBS family (313 aa)
 
 
  0.958
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme (460 aa)
  0.925
GEAM_0368
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme (459 aa)
  0.923
GEAM_3828
Protein involved in uroporphyrinogen-III synthase activity and tetrapyrrole biosynthetic process (216 aa)
   
 
  0.787
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (354 aa)
 
   
  0.780
GEAM_2569
Bcp family thiol peroxidase; Protein involved in oxidoreductase activity, antioxidant activity and oxidation-reduction process (155 aa)
 
        0.728
GEAM_0342
H+/Cl-exchange transporter; Protein involved in voltage-gated chloride channel activity, ion channel activity, biological_process, chloride transport and transmembrane transport (521 aa)
              0.720
rnhA
Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (155 aa)
            0.688
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
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