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GEAM_0368 protein (Ewingella americana) - STRING interaction network
"GEAM_0368" - Siroheme synthase in Ewingella americana
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Predicted Interactions
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textmining
co-expression
protein homology
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GEAM_0368Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme (459 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps; Belongs to the HMBS family (313 aa)
 
  0.995
cysI
Sulfite reductase [NADPH] hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family (578 aa)
 
  0.989
GEAM_1112
Delta-aminolevulinic acid dehydratase; Protein involved in porphobilinogen synthase activity, metal ion binding and tetrapyrrole biosynthetic process; Belongs to the ALAD family (324 aa)
 
  0.978
cysC
Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate (206 aa)
 
   
  0.978
cysD
Protein involved in catalytic activity, sulfate adenylyltransferase (ATP) activity, sulfate assimilation, metabolic process and sulfate reduction (302 aa)
 
   
  0.962
cysN
Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily (475 aa)
 
   
  0.962
GEAM_3828
Protein involved in uroporphyrinogen-III synthase activity and tetrapyrrole biosynthetic process (216 aa)
   
 
  0.952
nirD
Protein involved in nitrite reductase [NAD(P)H] activity, oxidoreductase activity, 2 iron, 2 sulfur cluster binding, nitrate assimilation and oxidation-reduction process (108 aa)
 
   
  0.933
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA); Belongs to the glutamyl-tRNA reductase family (420 aa)
  0.931
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (354 aa)
   
 
  0.927
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
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