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alaS protein (Ewingella americana) - STRING interaction network
"alaS" - Alanine--tRNA ligase in Ewingella americana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
alaSAlanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family (875 aa)    
Predicted Functional Partners:
pheT
Phenylalanine--tRNA ligase beta subunit; Protein involved in tRNA binding, RNA binding, ATP binding, magnesium ion binding, phenylalanine-tRNA ligase activity, nucleotide binding, phenylalanyl-tRNA aminoacylation and tRNA processing; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily (795 aa)
 
 
  0.939
ileS
Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as ’pretransfer’ editing and involves the hydrolysis of activated Val-AMP. The other activity is designated ’posttransfer’ editing and involves deacylation of mischarged Val-tRNA(Ile) (938 aa)
 
 
  0.921
leuS
Leucine--tRNA ligase; Protein involved in ATP binding, nucleotide binding, aminoacyl-tRNA ligase activity, aminoacyl-tRNA editing activity, leucine-tRNA ligase activity, leucyl-tRNA aminoacylation and tRNA aminoacylation for protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family (860 aa)
 
 
  0.910
thrS
Threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction- L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (642 aa)
   
 
  0.896
metG
Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (618 aa)
   
 
  0.853
cysS
Cysteine--tRNA ligase; Protein involved in ATP binding, nucleotide binding, cysteine-tRNA ligase activity, aminoacyl-tRNA ligase activity, cysteinyl-tRNA aminoacylation and tRNA aminoacylation for protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family (463 aa)
 
   
  0.819
lepA
Elongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (599 aa)
 
   
  0.807
hflB
ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family (610 aa)
 
   
  0.806
pheS
Phenylalanine--tRNA ligase alpha subunit; Protein involved in ATP binding, phenylalanine-tRNA ligase activity, nucleotide binding, aminoacyl-tRNA ligase activity, tRNA binding, phenylalanyl-tRNA aminoacylation and tRNA aminoacylation; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily (327 aa)
 
   
  0.792
serS
Serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (430 aa)
 
 
  0.785
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
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