node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | gmk | GEAM_2698 | GEAM_3710 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.969 |
apt | gpt | GEAM_2698 | GEAM_0542 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.939 |
apt | guaA | GEAM_2698 | GEAM_0666 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.989 |
apt | guaC | GEAM_2698 | GEAM_0289 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.925 |
apt | map | GEAM_2698 | GEAM_2923 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.401 |
apt | purL | GEAM_2698 | GEAM_2805 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamine amidotransferase subunit of phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.760 |
apt | rdgB | GEAM_2698 | GEAM_3089 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Nucleoside 5-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.630 |
argS | gmk | GEAM_1829 | GEAM_3710 | arginyl-tRNA synthetase; Protein involved in nucleotide binding, arginine-tRNA ligase activity, ATP binding, aminoacyl-tRNA ligase activity, arginyl-tRNA aminoacylation and tRNA aminoacylation for protein translation. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.492 |
argS | guaA | GEAM_1829 | GEAM_0666 | arginyl-tRNA synthetase; Protein involved in nucleotide binding, arginine-tRNA ligase activity, ATP binding, aminoacyl-tRNA ligase activity, arginyl-tRNA aminoacylation and tRNA aminoacylation for protein translation. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.985 |
argS | purL | GEAM_1829 | GEAM_2805 | arginyl-tRNA synthetase; Protein involved in nucleotide binding, arginine-tRNA ligase activity, ATP binding, aminoacyl-tRNA ligase activity, arginyl-tRNA aminoacylation and tRNA aminoacylation for protein translation. | Glutamine amidotransferase subunit of phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.673 |
argS | rplK | GEAM_1829 | GEAM_3922 | arginyl-tRNA synthetase; Protein involved in nucleotide binding, arginine-tRNA ligase activity, ATP binding, aminoacyl-tRNA ligase activity, arginyl-tRNA aminoacylation and tRNA aminoacylation for protein translation. | LSU ribosomal protein L11p (L12e); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.598 |
gmk | apt | GEAM_3710 | GEAM_2698 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.969 |
gmk | argS | GEAM_3710 | GEAM_1829 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | arginyl-tRNA synthetase; Protein involved in nucleotide binding, arginine-tRNA ligase activity, ATP binding, aminoacyl-tRNA ligase activity, arginyl-tRNA aminoacylation and tRNA aminoacylation for protein translation. | 0.492 |
gmk | gpt | GEAM_3710 | GEAM_0542 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.969 |
gmk | guaA | GEAM_3710 | GEAM_0666 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.991 |
gmk | guaC | GEAM_3710 | GEAM_0289 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.921 |
gmk | map | GEAM_3710 | GEAM_2923 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.532 |
gmk | purL | GEAM_3710 | GEAM_2805 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Glutamine amidotransferase subunit of phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.759 |
gmk | rdgB | GEAM_3710 | GEAM_3089 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside 5-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.428 |
gpt | apt | GEAM_0542 | GEAM_2698 | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.939 |