STRINGSTRING
sdhD protein (Ewingella americana) - STRING interaction network
"sdhD" - Succinate dehydrogenase hydrophobic membrane anchor subunit in Ewingella americana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhDSuccinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) (115 aa)    
Predicted Functional Partners:
sdhC
Succinate dehydrogenase cytochrome b556 subunit; Protein involved in oxidoreductase activity, acting on the CH-CH group of donors, succinate dehydrogenase activity and tricarboxylic acid cycle (80 aa)
  0.999
sdhA
Succinate dehydrogenase flavoprotein subunit; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, flavin adenine dinucleotide binding, oxidation-reduction process, tricarboxylic acid cycle and electron transport chain; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily (588 aa)
  0.997
GEAM_0790
Succinate dehydrogenase iron-sulfur subunit; Protein involved in iron-sulfur cluster binding, electron carrier activity, oxidoreductase activity, tricarboxylic acid cycle, aerobic respiration, anaerobic respiration and oxidation-reduction process; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family (238 aa)
 
  0.990
sucA
2-oxoglutarate dehydrogenase E1 component; Protein involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamine pyrophosphate binding, tricarboxylic acid cycle, lysine catabolic process, tryptophan metabolic process, metabolic process and oxidation-reduction process (935 aa)
 
 
  0.974
sucD
Succinate--CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit (290 aa)
   
 
  0.969
sucC
Succinate--CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (388 aa)
   
 
  0.967
GEAM_3006
Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)- malate; Belongs to the class-I fumarase family (549 aa)
   
 
  0.967
frdA
Fumarate reductase flavoprotein subunit; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, flavin adenine dinucleotide binding, anaerobic respiration, oxidation-reduction process and electron transport chain (553 aa)
 
  0.966
sucB
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (408 aa)
   
 
  0.951
GEAM_3004
Fumarate reductase flavoprotein subunit; Protein involved in FMN binding, oxidoreductase activity, succinate dehydrogenase activity and oxidation-reduction process (925 aa)
   
  0.947
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
Server load: low (11%) [HD]