STRINGSTRING
sdhA protein (Ewingella americana) - STRING interaction network
"sdhA" - Succinate dehydrogenase flavoprotein subunit in Ewingella americana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhASuccinate dehydrogenase flavoprotein subunit; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, flavin adenine dinucleotide binding, oxidation-reduction process, tricarboxylic acid cycle and electron transport chain; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily (588 aa)    
Predicted Functional Partners:
sdhD
Succinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) (115 aa)
  0.997
nifJ
Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1177 aa)
   
  0.997
sdhC
Succinate dehydrogenase cytochrome b556 subunit; Protein involved in oxidoreductase activity, acting on the CH-CH group of donors, succinate dehydrogenase activity and tricarboxylic acid cycle (80 aa)
  0.997
GEAM_0790
Succinate dehydrogenase iron-sulfur subunit; Protein involved in iron-sulfur cluster binding, electron carrier activity, oxidoreductase activity, tricarboxylic acid cycle, aerobic respiration, anaerobic respiration and oxidation-reduction process; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family (238 aa)
 
  0.994
nuoD
NADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family (599 aa)
   
  0.991
GEAM_3970
Succinate dehydrogenase iron-sulfur subunit; Protein involved in iron-sulfur cluster binding, electron carrier activity, oxidoreductase activity, tricarboxylic acid cycle, aerobic respiration, anaerobic respiration and oxidation-reduction process; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family (244 aa)
 
  0.971
GEAM_3006
Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)- malate; Belongs to the class-I fumarase family (549 aa)
   
 
  0.942
sucD
Succinate--CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit (290 aa)
 
  0.935
sucC
Succinate--CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (388 aa)
 
  0.928
nuoF
NADH-quinone oxidoreductase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain; Belongs to the complex I 51 kDa subunit family (456 aa)
   
  0.914
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
Server load: low (18%) [HD]