STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucCsuccinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)    
Predicted Functional Partners:
sucD
succinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.999
GEAM_0790
Protein involved in iron-sulfur cluster binding, electron carrier activity, oxidoreductase activity, tricarboxylic acid cycle, aerobic respiration, anaerobic respiration and oxidation-reduction process; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.996
sdhC
Succinate dehydrogenase cytochrome b556 subunit; Protein involved in oxidoreductase activity, acting on the CH-CH group of donors, succinate dehydrogenase activity and tricarboxylic acid cycle.
  
 
 0.995
sdhD
Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
 
 0.995
sucB
Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.994
sdhA
Succinate dehydrogenase flavoprotein subunit; Protein involved in oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, flavin adenine dinucleotide binding, oxidation-reduction process, tricarboxylic acid cycle and electron transport chain; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.993
nuoD
NADH-ubiquinone oxidoreductase chain C/NADH-ubiquinone oxidoreductase chain D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family.
  
 
 0.992
nifJ
Protein involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, electron carrier activity, iron-sulfur cluster binding, thiamine pyrophosphate binding, catalytic activity, oxidoreductase activity, iron ion binding, oxidation-reduction process, electron transport chain and metabolic process.
  
 
 0.989
sucA
2-oxoglutarate dehydrogenase E1 component; Protein involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamine pyrophosphate binding, tricarboxylic acid cycle, lysine catabolic process, tryptophan metabolic process, metabolic process and oxidation-reduction process.
 
 0.985
GEAM_3970
Protein involved in iron-sulfur cluster binding, electron carrier activity, oxidoreductase activity, tricarboxylic acid cycle, aerobic respiration, anaerobic respiration and oxidation-reduction process; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.984
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana ATCC 33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
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