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hisG protein (Ewingella americana) - STRING interaction network
"hisG" - Protein involved in ATP phosphoribosyltransferase activity, magnesium ion binding and histidine biosynthetic process in Ewingella americana
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisGProtein involved in ATP phosphoribosyltransferase activity, magnesium ion binding and histidine biosynthetic process (289 aa)    
Predicted Functional Partners:
hisE
Histidine biosynthesis bifunctional protein HisIE; Protein involved in phosphoribosyl-AMP cyclohydrolase activity, phosphoribosyl-ATP diphosphatase activity and histidine biosynthetic process; In the N-terminal section; belongs to the PRA-CH family (213 aa)
 
 
  0.999
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (257 aa)
 
  0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (438 aa)
 
  0.998
hisC
Protein involved in pyridoxal phosphate binding, histidinol-phosphate transaminase activity, histidine biosynthetic process and biosynthetic process; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily (378 aa)
 
 
  0.998
hisB
Histidine biosynthesis bifunctional protein HisB; Protein involved in imidazoleglycerol-phosphate dehydratase activity, histidinol-phosphatase activity, phosphatase activity and histidine biosynthetic process (360 aa)
 
   
  0.998
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (196 aa)
 
 
  0.996
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process (245 aa)
 
 
  0.995
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (491 aa)
 
 
  0.900
hisS
Protein involved in histidine-tRNA ligase activity, ATP binding and histidyl-tRNA aminoacylation (414 aa)
 
 
  0.827
GEAM_0210
Aspartokinase/homoserine dehydrogenase; Protein involved in NADP binding, oxidoreductase activity, aspartate kinase activity, cellular amino acid biosynthetic process, oxidation-reduction process and cellular amino acid metabolic process (819 aa)
 
 
  0.807
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
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