STRINGSTRING
GEAM_1571 protein (Ewingella americana) - STRING interaction network
"GEAM_1571" - Aminopyrimidine aminohydrolase in Ewingella americana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GEAM_1571Aminopyrimidine aminohydrolase; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5’ of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino- 5-hydroxymethyl-2-methylpyrimidine (HMP); Belongs to the TenA family (195 aa)    
Predicted Functional Partners:
thiD
Hydroxymethylpyrimidine phosphate kinase; Protein involved in phosphomethylpyrimidine kinase activity and thiamine biosynthetic process (266 aa)
   
 
  0.855
GEAM_1570
annotation not available (280 aa)
 
          0.825
GEAM_0692
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family (171 aa)
 
 
  0.705
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (652 aa)
       
  0.678
thiE
Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP); Belongs to the thiamine-phosphate synthase family (218 aa)
       
  0.678
GEAM_0691
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family (91 aa)
   
 
  0.660
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family (328 aa)
       
    0.613
GEAM_1564
Resiniferatoxin-binding phosphotriesterase-related protein; Protein involved in hydrolase activity, acting on ester bonds, zinc ion binding and catabolic process (365 aa)
 
          0.582
GEAM_1569
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway (304 aa)
 
          0.580
GEAM_1551
annotation not available (257 aa)
 
          0.561
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
Server load: low (11%) [HD]