STRINGSTRING
GEAM_1588 protein (Ewingella americana) - STRING interaction network
"GEAM_1588" - Protein involved in oxidoreductase activity, molybdenum ion binding, formate dehydrogenase in Ewingella americana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GEAM_1588Protein involved in oxidoreductase activity, molybdenum ion binding, formate dehydrogenase (NAD+) activity, 4 iron, 4 sulfur cluster binding and oxidation-reduction process; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family (768 aa)    
Predicted Functional Partners:
nifJ
Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1177 aa)
   
  0.957
GEAM_0095
Glutamate synthase [NADPH] large chain; Protein involved in oxidoreductase activity, acting on the CH-NH2 group of donors, glutamate synthase activity, oxidoreductase activity, oxidation-reduction process, glutamate biosynthetic process, nitrogen compound metabolic process and metabolic process (1485 aa)
       
  0.933
fdhD
Sulfur carrier protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH (281 aa)
 
  0.876
nuoD
NADH-quinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family (599 aa)
   
 
  0.849
dmsB
Anaerobic dimethyl sulfoxide reductase chain B; Protein involved in electron carrier activity and iron-sulfur cluster binding (205 aa)
   
  0.836
GEAM_2546
NADP-dependent malic enzyme; Protein involved in NAD binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, transferase activity, transferring acyl groups, oxidation-reduction process and metabolic process (759 aa)
       
  0.766
uca
Urea carboxylase; Protein involved in ligase activity, ATP binding, catalytic activity, peptidyl-prolyl cis-trans isomerase activity, urea metabolic process, metabolic process and protein folding (1212 aa)
       
  0.753
GEAM_3006
Fumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)- malate; Belongs to the class-I fumarase family (549 aa)
         
  0.752
birA
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5’-adenylate (BirA-bio- 5’-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (319 aa)
       
    0.750
GEAM_1622
annotation not available (539 aa)
   
 
  0.677
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
Server load: low (9%) [HD]