STRINGSTRING
GEAM_1703 protein (Ewingella americana) - STRING interaction network
"GEAM_1703" - Fumarate and nitrate reduction regulatory protein in Ewingella americana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GEAM_1703Fumarate and nitrate reduction regulatory protein; Protein involved in sequence-specific DNA binding transcription factor activity and regulation of transcription, DNA-templated (309 aa)    
Predicted Functional Partners:
GEAM_0095
Glutamate synthase [NADPH] large chain; Protein involved in oxidoreductase activity, acting on the CH-NH2 group of donors, glutamate synthase activity, oxidoreductase activity, oxidation-reduction process, glutamate biosynthetic process, nitrogen compound metabolic process and metabolic process (1485 aa)
   
 
  0.940
nifJ
Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1177 aa)
   
 
  0.904
GEAM_1515
Bifunctional protein PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family (1318 aa)
       
  0.778
GEAM_1702
Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction- the enzyme is irreversibly inactivated (194 aa)
              0.766
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family (957 aa)
     
 
    0.765
GEAM_1704
Protein involved in response to stress (319 aa)
 
   
  0.744
fadB
Fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family (726 aa)
     
 
  0.720
fadJ
Fatty acid oxidation complex subunit alpha; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family (716 aa)
     
 
  0.720
rpoD
RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (612 aa)
       
 
  0.634
hemN
Coproporphyrinogen-III oxidase; Protein involved in catalytic activity, iron-sulfur cluster binding, coproporphyrinogen oxidase activity, porphyrin-containing compound biosynthetic process and oxidation-reduction process; Belongs to the anaerobic coproporphyrinogen-III oxidase family (468 aa)
 
 
  0.619
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
Server load: low (15%) [HD]