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nadE protein (Ewingella americana) - STRING interaction network
"nadE" - NH(3)-dependent NAD(+) synthetase in Ewingella americana
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Predicted Interactions
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textmining
co-expression
protein homology
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nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source (276 aa)    
Predicted Functional Partners:
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (221 aa)
   
 
  0.894
pncB
Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP (401 aa)
 
 
  0.879
nadK
NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2’-hydroxyl of the adenosine moiety of NAD to yield NADP (292 aa)
   
 
  0.872
GEAM_0198
Protein involved in sequence-specific DNA binding, DNA binding, catalytic activity, NAD biosynthetic process, transport, regulation of transcription, DNA-templated, pyridine nucleotide biosynthetic process and biosynthetic process (419 aa)
       
  0.866
sthA
Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family (466 aa)
   
    0.798
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (525 aa)
   
   
  0.793
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (440 aa)
   
 
    0.789
birA
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5’-adenylate (BirA-bio- 5’-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (319 aa)
   
   
  0.781
nadC
Quinolinate phosphoribosyltransferase; Protein involved in transferase activity, transferring pentosyl groups, nicotinate-nucleotide diphosphorylase (carboxylating) activity, pyridine nucleotide biosynthetic process and NAD biosynthetic process; Belongs to the NadC/ModD family (297 aa)
   
 
  0.773
GEAM_1705
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (463 aa)
     
 
  0.772
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
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