STRINGSTRING
acnA protein (Ewingella americana) - STRING interaction network
"acnA" - Aconitate hydratase in Ewingella americana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (891 aa)    
Predicted Functional Partners:
gltA
Citrate synthase; Protein involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer, citrate (Si)-synthase activity, tricarboxylic acid cycle and cellular carbohydrate metabolic process (428 aa)
 
  0.980
GEAM_4170
annotation not available (390 aa)
 
  0.960
icd
Isocitrate dehydrogenase [NADP]; Protein involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, isocitrate dehydrogenase (NADP+) activity, NAD binding, magnesium ion binding, tricarboxylic acid cycle and oxidation-reduction process (417 aa)
 
  0.936
acnB
Protein involved in aconitate hydratase activity, 4 iron, 4 sulfur cluster binding, tricarboxylic acid cycle and metabolic process; Belongs to the aconitase/IPM isomerase family (865 aa)
   
  0.922
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family (792 aa)
   
 
  0.922
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (365 aa)
   
  0.911
nifJ
Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1177 aa)
   
   
  0.879
sucC
Succinate--CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (388 aa)
 
  0.858
sucA
2-oxoglutarate dehydrogenase E1 component; Protein involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamine pyrophosphate binding, tricarboxylic acid cycle, lysine catabolic process, tryptophan metabolic process, metabolic process and oxidation-reduction process (935 aa)
   
 
  0.853
aceA
Isocitrate lyase; Protein involved in catalytic activity, isocitrate lyase activity, tricarboxylic acid cycle, metabolic process and carboxylic acid metabolic process (437 aa)
     
 
  0.840
Your Current Organism:
Ewingella americana
NCBI taxonomy Id: 910964
Other names: E. americana ATCC 33852, Ewingella americana, Ewingella americana ATCC 33852, Ewingella americana ATCC33852, Ewingella americana str. ATCC 33852, Ewingella americana strain ATCC 33852
Server load: low (10%) [HD]