STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCNAProliferating cell nuclear antigen. (190 aa)    
Predicted Functional Partners:
RFC4
Replication factor C subunit 4.
  
 0.998
AS28_07169
Werner syndrome ATP-dependent helicase.
  
 0.997
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
 0.997
RFC3
Replication factor C subunit 3.
  
 0.996
MSH6
DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR).
   
 0.995
RFC2
Replication factor C subunit 2.
  
 0.994
LIG4
DNA ligase.
   
 0.993
RFC1
Replication factor C subunit 1.
   
 0.990
POLH
DNA polymerase eta.
   
 0.989
RAD18
E3 ubiquitin-protein ligase RAD18.
   
 0.987
Your Current Organism:
Pygoscelis adeliae
NCBI taxonomy Id: 9238
Other names: Adelie penguin, P. adeliae, Pygoscelis adelia
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