node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AS28_07169 | FEN1 | A0A093NHB6 | A0A093NXU2 | Werner syndrome ATP-dependent helicase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.998 |
AS28_07169 | LIG4 | A0A093NHB6 | A0A093PBC9 | Werner syndrome ATP-dependent helicase. | DNA ligase. | 0.733 |
AS28_07169 | MSH6 | A0A093NHB6 | A0A093QTJ2 | Werner syndrome ATP-dependent helicase. | DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). | 0.906 |
AS28_07169 | PCNA | A0A093NHB6 | A0A093NX18 | Werner syndrome ATP-dependent helicase. | Proliferating cell nuclear antigen. | 0.997 |
AS28_07169 | POLH | A0A093NHB6 | A0A093PD02 | Werner syndrome ATP-dependent helicase. | DNA polymerase eta. | 0.941 |
AS28_07169 | RAD18 | A0A093NHB6 | A0A093R043 | Werner syndrome ATP-dependent helicase. | E3 ubiquitin-protein ligase RAD18. | 0.864 |
AS28_07169 | RFC1 | A0A093NHB6 | A0A093P9I8 | Werner syndrome ATP-dependent helicase. | Replication factor C subunit 1. | 0.976 |
AS28_07169 | RFC2 | A0A093NHB6 | A0A093NG03 | Werner syndrome ATP-dependent helicase. | Replication factor C subunit 2. | 0.938 |
AS28_07169 | RFC3 | A0A093NHB6 | A0A093RFK4 | Werner syndrome ATP-dependent helicase. | Replication factor C subunit 3. | 0.941 |
AS28_07169 | RFC4 | A0A093NHB6 | A0A093NUA1 | Werner syndrome ATP-dependent helicase. | Replication factor C subunit 4. | 0.941 |
FEN1 | AS28_07169 | A0A093NXU2 | A0A093NHB6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Werner syndrome ATP-dependent helicase. | 0.998 |
FEN1 | LIG4 | A0A093NXU2 | A0A093PBC9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.871 |
FEN1 | MSH6 | A0A093NXU2 | A0A093QTJ2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). | 0.892 |
FEN1 | PCNA | A0A093NXU2 | A0A093NX18 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen. | 0.997 |
FEN1 | RAD18 | A0A093NXU2 | A0A093R043 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | E3 ubiquitin-protein ligase RAD18. | 0.491 |
FEN1 | RFC1 | A0A093NXU2 | A0A093P9I8 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 1. | 0.876 |
FEN1 | RFC2 | A0A093NXU2 | A0A093NG03 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 2. | 0.875 |
FEN1 | RFC3 | A0A093NXU2 | A0A093RFK4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 3. | 0.906 |
FEN1 | RFC4 | A0A093NXU2 | A0A093NUA1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 4. | 0.897 |
LIG4 | AS28_07169 | A0A093PBC9 | A0A093NHB6 | DNA ligase. | Werner syndrome ATP-dependent helicase. | 0.733 |