STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DHX58Putative ATP-dependent RNA helicase DHX58. (639 aa)    
Predicted Functional Partners:
IFIH1
Interferon-induced helicase C domain-containing protein 1.
  
0.975
USP18
Ubl carboxyl-terminal hydrolase 18.
   
 
 0.888
AS28_07169
Werner syndrome ATP-dependent helicase.
   
 
 0.878
FANCL
E3 ubiquitin-protein ligase FANCL.
    
 0.823
FANCG
Fanconi anemia group G protein.
    
 0.816
FANCB
Fanconi anemia group B protein.
   
 0.808
MEIOB
Meiosis-specific with OB domain-containing protein.
    
 0.787
FANCC
Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
    
 0.780
AS28_12748
Fanconi anemia-associated protein of 24 kDa.
    
 0.762
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
   
 
 0.684
Your Current Organism:
Pygoscelis adeliae
NCBI taxonomy Id: 9238
Other names: Adelie penguin, P. adeliae, Pygoscelis adelia
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