STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1487 aa)    
Predicted Functional Partners:
F7D8T5_ORNAN
EBP50_C domain-containing protein.
   
 0.936
PRKACA
Protein kinase cAMP-activated catalytic subunit alpha.
 
 
 0.934
PRKACB
Uncharacterized protein.
 
 
 0.934
TJP1-2
PDZ domain-containing protein.
     
 0.918
PRKAA1
Non-specific serine/threonine protein kinase.
   
 0.916
PRKAB2
Protein kinase AMP-activated non-catalytic subunit beta 2.
   
 0.914
PRKAG2
Protein kinase AMP-activated non-catalytic subunit gamma 2.
   
  0.904
PRKAG3
CBS domain-containing protein.
   
  0.903
PRKAG1
CBS domain-containing protein.
   
  0.901
GOPC
PDZ domain-containing protein.
   
 0.872
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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