STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (462 aa)    
Predicted Functional Partners:
NCSTN
Nicastrin.
   
 0.998
PSENEN
Uncharacterized protein.
    
 0.998
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
  
 
0.998
APH1A
Aph-1 homolog A, gamma-secretase subunit.
   
 0.974
APH1B
Aph-1 homolog B, gamma-secretase subunit.
   
 0.974
NOTCH2
Notch receptor 2.
    
 0.920
ITPR3
Inositol 1,4,5-trisphosphate receptor type 3.
    
 0.916
RYR3
Ryanodine receptor 3.
    
 0.916
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1.
    
 0.916
ERN1
Endoplasmic reticulum to nucleus signaling 1.
    
 0.916
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus laniarius, Tasmanian devil
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.