STRINGSTRING
BCL2L2 protein (Sarcophilus harrisii) - STRING interaction network
"BCL2L2" - BCL2-like 2 in Sarcophilus harrisii
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BCL2L2BCL2-like 2 (209 aa)    
Predicted Functional Partners:
BID
BH3 interacting domain death agonist (194 aa)
       
 
  0.905
BCL2L11
BCL2-like 11 (apoptosis facilitator) (200 aa)
       
 
  0.888
GABPB1
GA binding protein transcription factor, beta subunit 1 (233 aa)
       
      0.867
BMF
Bcl2 modifying factor (184 aa)
       
 
  0.803
GABPB2
GA binding protein transcription factor, beta subunit 2 (464 aa)
       
      0.790
MCL1
MCL1, BCL2 family apoptosis regulator; Myeloid cell leukemia 1 (262 aa)
           
  0.769
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (1255 aa)
     
 
  0.757
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family (371 aa)
     
 
  0.752
BCL2A1
BCL2-related protein A1 (172 aa)
           
  0.721
ENSSHAG00000014841
Uncharacterized protein (218 aa)
 
   
 
  0.686
Your Current Organism:
Sarcophilus harrisii
NCBI taxonomy Id: 9305
Other names: S. harrisii, Sarcophilus harrisii, Sarcophilus laniarius, Tasmanian devil
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