STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (242 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.993
pyrR
Phosphoribosyl transferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
  
 
 0.986
pyrB
COG540 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.948
upp
COG35 Uracil phosphoribosyltransferase [Nucleotide transport and metabolism].
  
 
 0.946
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
  
 0.939
carB
COG458 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism].
  
  
 0.939
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
 
 0.938
carA
COG505 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Belongs to the CarA family.
  
  
 0.920
surE
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.916
ABV50715.1
ATP/GTP-binding site motif A (P-loop); COG572 Uridine kinase [Nucleotide transport and metabolism].
   
 0.911
Your Current Organism:
Prochlorococcus marinus MIT9215
NCBI taxonomy Id: 93060
Other names: P. marinus str. MIT 9215, Prochlorococcus marinus MIT 9215, Prochlorococcus marinus str. MIT 9215, Prochlorococcus sp. MIT 9215, Prochlorococcus sp. MIT9215
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