STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (511 aa)    
Predicted Functional Partners:
SiRe_2622
Lactate/malate dehydrogenase; Belongs to the LDH/MDH superfamily.
     
 0.924
SiRe_1199
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.917
pckG
Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
     
 0.916
eno
Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
  
  0.912
SiRe_1105
Pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.907
SiRe_2618
2-methylcitrate synthase/citrate synthase II.
     
 0.838
SiRe_0069
P-loop ATPase/GTPase-like protein.
       0.802
SiRe_0741
Malate synthase.
     
  0.800
SiRe_1068
Formate dehydrogenase, alpha subunit.
     
  0.800
SiRe_2176
Cyclase family protein.
     
  0.800
Your Current Organism:
Sulfolobus islandicus
NCBI taxonomy Id: 930945
Other names: S. islandicus REY15A, Sulfolobus islandicus REY15A, Sulfolobus islandicus str. REY15A, Sulfolobus islandicus strain REY15A
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.