node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ahos_0981 | Ahos_1143 | Ahos_0981 | Ahos_1143 | Aminotransferase class I and II. | Phosphoribosyl-AMP cyclohydrolase. | 0.934 |
Ahos_0981 | Ahos_1149 | Ahos_0981 | Ahos_1149 | Aminotransferase class I and II. | Histidine biosynthesis protein; Belongs to the HisA/HisF family. | 0.930 |
Ahos_0981 | Ahos_1151 | Ahos_0981 | Ahos_1151 | Aminotransferase class I and II. | Histidinol-phosphate aminotransferase. | 0.919 |
Ahos_0981 | hisB | Ahos_0981 | Ahos_1148 | Aminotransferase class I and II. | Imidazoleglycerol-phosphate dehydratase. | 0.993 |
Ahos_0981 | hisD | Ahos_0981 | Ahos_1146 | Aminotransferase class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.945 |
Ahos_0981 | hisE | Ahos_0981 | Ahos_1145 | Aminotransferase class I and II. | phosphoribosyl-ATP diphosphatase. | 0.902 |
Ahos_0981 | hisF | Ahos_0981 | Ahos_1147 | Aminotransferase class I and II. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.938 |
Ahos_0981 | hisG | Ahos_0981 | Ahos_1150 | Aminotransferase class I and II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.939 |
Ahos_0981 | hisH | Ahos_0981 | Ahos_1144 | Aminotransferase class I and II. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.938 |
Ahos_1143 | Ahos_0981 | Ahos_1143 | Ahos_0981 | Phosphoribosyl-AMP cyclohydrolase. | Aminotransferase class I and II. | 0.934 |
Ahos_1143 | Ahos_1149 | Ahos_1143 | Ahos_1149 | Phosphoribosyl-AMP cyclohydrolase. | Histidine biosynthesis protein; Belongs to the HisA/HisF family. | 0.999 |
Ahos_1143 | Ahos_1151 | Ahos_1143 | Ahos_1151 | Phosphoribosyl-AMP cyclohydrolase. | Histidinol-phosphate aminotransferase. | 0.988 |
Ahos_1143 | hisB | Ahos_1143 | Ahos_1148 | Phosphoribosyl-AMP cyclohydrolase. | Imidazoleglycerol-phosphate dehydratase. | 0.999 |
Ahos_1143 | hisD | Ahos_1143 | Ahos_1146 | Phosphoribosyl-AMP cyclohydrolase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
Ahos_1143 | hisE | Ahos_1143 | Ahos_1145 | Phosphoribosyl-AMP cyclohydrolase. | phosphoribosyl-ATP diphosphatase. | 0.999 |
Ahos_1143 | hisF | Ahos_1143 | Ahos_1147 | Phosphoribosyl-AMP cyclohydrolase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
Ahos_1143 | hisG | Ahos_1143 | Ahos_1150 | Phosphoribosyl-AMP cyclohydrolase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
Ahos_1143 | hisH | Ahos_1143 | Ahos_1144 | Phosphoribosyl-AMP cyclohydrolase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
Ahos_1143 | map | Ahos_1143 | Ahos_0588 | Phosphoribosyl-AMP cyclohydrolase. | Methionine aminopeptidase, type II; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. | 0.556 |
Ahos_1149 | Ahos_0981 | Ahos_1149 | Ahos_0981 | Histidine biosynthesis protein; Belongs to the HisA/HisF family. | Aminotransferase class I and II. | 0.930 |