STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL1R1Interleukin-1 receptor type 1. (484 aa)    
Predicted Functional Partners:
IL1RN
Interleukin 1 receptor antagonist.
   
 0.986
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
    
 0.985
LOC103115821
Interleukin-1 receptor accessory protein isoform X2.
   
 0.976
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
 0.975
IL1A
Interleukin-1; Belongs to the IL-1 family.
   
 0.971
ENSEEUP00000005767
annotation not available
    
 0.959
IRAK1
Interleukin-1 receptor-associated kinase 1.
    
 0.949
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.946
IL36G
Interleukin-36 gamma-like.
    
 0.942
IL36A
Interleukin-1.
    
 0.942
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.