node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK47459.1 | ABK48683.1 | Shewana3_1224 | Shewana3_2454 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO3317 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO2001 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.969 |
ABK47459.1 | dut | Shewana3_1224 | Shewana3_3772 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO3317 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
ABK47459.1 | surE | Shewana3_1224 | Shewana3_1121 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO3317 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 3'-nucleotidase / exopolyphosphatase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.910 |
ABK47459.1 | tdk | Shewana3_1224 | Shewana3_1410 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO3317 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | PFAM: thymidine kinase; KEGG: son:SO3140 thymidine kinase. | 0.913 |
ABK47459.1 | thyA | Shewana3_1224 | Shewana3_3039 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO3317 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.902 |
ABK47459.1 | tmk | Shewana3_1224 | Shewana3_1766 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO3317 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.913 |
ABK48000.1 | dut | Shewana3_1767 | Shewana3_3772 | TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: son:SO2612 DNA polymerase III, delta prime subunit. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.427 |
ABK48000.1 | tmk | Shewana3_1767 | Shewana3_1766 | TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: son:SO2612 DNA polymerase III, delta prime subunit. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.951 |
ABK48199.1 | ABK48200.1 | Shewana3_1968 | Shewana3_1969 | PFAM: ribonucleotide reductase; KEGG: son:SO2416 ribonucleoside-diphosphate reductase beta chain. | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
ABK48199.1 | ndk | Shewana3_1968 | Shewana3_2272 | PFAM: ribonucleotide reductase; KEGG: son:SO2416 ribonucleoside-diphosphate reductase beta chain. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.918 |
ABK48199.1 | tmk | Shewana3_1968 | Shewana3_1766 | PFAM: ribonucleotide reductase; KEGG: son:SO2416 ribonucleoside-diphosphate reductase beta chain. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.933 |
ABK48200.1 | ABK48199.1 | Shewana3_1969 | Shewana3_1968 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | PFAM: ribonucleotide reductase; KEGG: son:SO2416 ribonucleoside-diphosphate reductase beta chain. | 0.999 |
ABK48200.1 | dut | Shewana3_1969 | Shewana3_3772 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.788 |
ABK48200.1 | ndk | Shewana3_1969 | Shewana3_2272 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.922 |
ABK48200.1 | tdk | Shewana3_1969 | Shewana3_1410 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | PFAM: thymidine kinase; KEGG: son:SO3140 thymidine kinase. | 0.423 |
ABK48200.1 | thyA | Shewana3_1969 | Shewana3_3039 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.877 |
ABK48200.1 | tmk | Shewana3_1969 | Shewana3_1766 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.947 |
ABK48683.1 | ABK47459.1 | Shewana3_2454 | Shewana3_1224 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO2001 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO3317 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.969 |
ABK48683.1 | dut | Shewana3_2454 | Shewana3_3772 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO2001 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
ABK48683.1 | surE | Shewana3_2454 | Shewana3_1121 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: son:SO2001 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 3'-nucleotidase / exopolyphosphatase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.934 |