STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysG1Siroheme synthase [Includes: Uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (474 aa)    
Predicted Functional Partners:
cysG2
Siroheme synthase [Includes: Uroporphyrin-III C-methyltransferase; Urogen III methylase Uroporphyrinogen IIImethylase; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase].
 
 
0.988
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.982
hemD
Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.963
nirE
Uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 
0.950
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.948
cysH
Adenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite.
 
  
 0.936
cysI-2
Putative NADPH-sulfite reductase iron-sulfur protein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.936
cysI
Ferredoxin-dependent sulfite reductase.
 
  
 0.912
hemX
Uroporphyrin-III C-methyltransferase, putative.
     
 0.910
hemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
  
 0.903
Your Current Organism:
Bordetella petrii
NCBI taxonomy Id: 94624
Other names: B. petrii, Bordetella petrii von Wintzingerode et al. 2001, CCUG 43448, DSM 12804, strain Se-1111R
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.