node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | CTSS | ENSCJAP00000066046 | ENSCJAP00000012586 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Cathepsin S isoform 1 preproprotein; Belongs to the peptidase C1 family. | 0.600 |
AGT | PGC | ENSCJAP00000066046 | ENSCJAP00000048890 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | Gastricsin; Hydrolyzes a variety of proteins. | 0.548 |
CACNA1C | DISC1 | ENSCJAP00000001452 | ENSCJAP00000067221 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Disrupted in schizophrenia 1 protein isoform L. | 0.562 |
CACNA1C | DPYD | ENSCJAP00000001452 | ENSCJAP00000033649 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. | 0.637 |
CACNA1C | PGC | ENSCJAP00000001452 | ENSCJAP00000048890 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Gastricsin; Hydrolyzes a variety of proteins. | 0.523 |
CTSS | AGT | ENSCJAP00000012586 | ENSCJAP00000066046 | Cathepsin S isoform 1 preproprotein; Belongs to the peptidase C1 family. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.600 |
CTSS | PGC | ENSCJAP00000012586 | ENSCJAP00000048890 | Cathepsin S isoform 1 preproprotein; Belongs to the peptidase C1 family. | Gastricsin; Hydrolyzes a variety of proteins. | 0.441 |
DEFB114 | PGC | ENSCJAP00000021311 | ENSCJAP00000048890 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Gastricsin; Hydrolyzes a variety of proteins. | 0.507 |
DISC1 | CACNA1C | ENSCJAP00000067221 | ENSCJAP00000001452 | Disrupted in schizophrenia 1 protein isoform L. | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | 0.562 |
DISC1 | PGC | ENSCJAP00000067221 | ENSCJAP00000048890 | Disrupted in schizophrenia 1 protein isoform L. | Gastricsin; Hydrolyzes a variety of proteins. | 0.494 |
DPYD | CACNA1C | ENSCJAP00000033649 | ENSCJAP00000001452 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | 0.637 |
DPYD | PGC | ENSCJAP00000033649 | ENSCJAP00000048890 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. | Gastricsin; Hydrolyzes a variety of proteins. | 0.548 |
KLK5 | KLK7 | ENSCJAP00000062411 | ENSCJAP00000030559 | Kallikrein related peptidase 5; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.721 |
KLK5 | PGC | ENSCJAP00000062411 | ENSCJAP00000048890 | Kallikrein related peptidase 5; Belongs to the peptidase S1 family. | Gastricsin; Hydrolyzes a variety of proteins. | 0.561 |
KLK7 | KLK5 | ENSCJAP00000030559 | ENSCJAP00000062411 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Kallikrein related peptidase 5; Belongs to the peptidase S1 family. | 0.721 |
KLK7 | PGC | ENSCJAP00000030559 | ENSCJAP00000048890 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Gastricsin; Hydrolyzes a variety of proteins. | 0.505 |
PGC | AGT | ENSCJAP00000048890 | ENSCJAP00000066046 | Gastricsin; Hydrolyzes a variety of proteins. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. | 0.548 |
PGC | CACNA1C | ENSCJAP00000048890 | ENSCJAP00000001452 | Gastricsin; Hydrolyzes a variety of proteins. | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | 0.523 |
PGC | CTSS | ENSCJAP00000048890 | ENSCJAP00000012586 | Gastricsin; Hydrolyzes a variety of proteins. | Cathepsin S isoform 1 preproprotein; Belongs to the peptidase C1 family. | 0.441 |
PGC | DEFB114 | ENSCJAP00000048890 | ENSCJAP00000021311 | Gastricsin; Hydrolyzes a variety of proteins. | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | 0.507 |