node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD14 | TLR2 | ENSMFAP00000012746 | ENSMFAP00000011078 | Uncharacterized protein. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.962 |
CD14 | TLR4 | ENSMFAP00000012746 | ENSMFAP00000043191 | Uncharacterized protein. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.979 |
DCN | TLR2 | ENSMFAP00000036799 | ENSMFAP00000011078 | Decorin; May affect the rate of fibrils formation. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.953 |
DCN | TLR4 | ENSMFAP00000036799 | ENSMFAP00000043191 | Decorin; May affect the rate of fibrils formation. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.952 |
MYD88 | NFKB1 | ENSMFAP00000028875 | ENSMFAP00000002134 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Nuclear factor kappa B subunit 1. | 0.745 |
MYD88 | TIRAP | ENSMFAP00000028875 | ENSMFAP00000030041 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | TIR domain-containing protein. | 0.991 |
MYD88 | TLR1 | ENSMFAP00000028875 | ENSMFAP00000013794 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Toll-like receptor. | 0.986 |
MYD88 | TLR2 | ENSMFAP00000028875 | ENSMFAP00000011078 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.984 |
MYD88 | TLR4 | ENSMFAP00000028875 | ENSMFAP00000043191 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.998 |
MYD88 | TLR5 | ENSMFAP00000028875 | ENSMFAP00000013602 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.986 |
MYD88 | TOLLIP | ENSMFAP00000028875 | ENSMFAP00000016100 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | Toll interacting protein. | 0.969 |
NFKB1 | MYD88 | ENSMFAP00000002134 | ENSMFAP00000028875 | Nuclear factor kappa B subunit 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.745 |
NFKB1 | TIRAP | ENSMFAP00000002134 | ENSMFAP00000030041 | Nuclear factor kappa B subunit 1. | TIR domain-containing protein. | 0.403 |
NFKB1 | TLR1 | ENSMFAP00000002134 | ENSMFAP00000013794 | Nuclear factor kappa B subunit 1. | Toll-like receptor. | 0.434 |
NFKB1 | TLR2 | ENSMFAP00000002134 | ENSMFAP00000011078 | Nuclear factor kappa B subunit 1. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.960 |
NFKB1 | TLR4 | ENSMFAP00000002134 | ENSMFAP00000043191 | Nuclear factor kappa B subunit 1. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.950 |
NFKB1 | TLR5 | ENSMFAP00000002134 | ENSMFAP00000013602 | Nuclear factor kappa B subunit 1. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.945 |
TICAM2 | TIRAP | ENSMFAP00000011843 | ENSMFAP00000030041 | TIR domain-containing adaptor molecule 2. | TIR domain-containing protein. | 0.429 |
TICAM2 | TLR1 | ENSMFAP00000011843 | ENSMFAP00000013794 | TIR domain-containing adaptor molecule 2. | Toll-like receptor. | 0.408 |
TICAM2 | TLR2 | ENSMFAP00000011843 | ENSMFAP00000011078 | TIR domain-containing adaptor molecule 2. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.954 |