STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADAM2Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity) (735 aa)    
Predicted Functional Partners:
EGM_14711
Uncharacterized protein; Calmegin isoform X1
   
 
 0.862
PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 mRNA, 4 ESTs, 5 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 6 samples with support for all annotated introns
      
 0.747
EGM_10000
Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 mRNA, 5 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments, including 2 samples with support for all annotated introns
   
  
 0.743
CCDC54
Coiled-coil domain-containing protein 54
   
  
 0.740
SPAM1
Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid
   
  
 0.737
EGM_06936
Acrosome formation-associated factor; Equatorin
      
 0.703
EGM_21098
Cysteine-rich secretory protein 1; Belongs to the CRISP family
      
 0.692
IZUMO1
Izumo sperm-egg fusion protein 1 isoform X1
   
  
 0.645
EGM_10806
Uncharacterized protein; fetuin-B isoform X1
      
 0.630
EGM_06944
Izumo sperm-egg fusion protein 3-like isoform X1
   
  
 0.588
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca fascicularis, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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