node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBFB | ETS1 | ENSMMUP00000070667 | ENSMMUP00000027254 | Core-binding factor subunit beta isoform 1. | ETS proto-oncogene 1, transcription factor. | 0.535 |
CBFB | FOXP3 | ENSMMUP00000070667 | ENSMMUP00000011310 | Core-binding factor subunit beta isoform 1. | Forkhead box P3. | 0.558 |
CBFB | RUNX1 | ENSMMUP00000070667 | ENSMMUP00000075631 | Core-binding factor subunit beta isoform 1. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.949 |
CBFB | RUNX1T1 | ENSMMUP00000070667 | ENSMMUP00000009560 | Core-binding factor subunit beta isoform 1. | RUNX1 partner transcriptional co-repressor 1. | 0.411 |
CSF1R | RUNX1 | ENSMMUP00000053422 | ENSMMUP00000075631 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.948 |
CSF1R | SPI1 | ENSMMUP00000053422 | ENSMMUP00000020473 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Spi-1 proto-oncogene. | 0.960 |
ETS1 | CBFB | ENSMMUP00000027254 | ENSMMUP00000070667 | ETS proto-oncogene 1, transcription factor. | Core-binding factor subunit beta isoform 1. | 0.535 |
ETS1 | RUNX1 | ENSMMUP00000027254 | ENSMMUP00000075631 | ETS proto-oncogene 1, transcription factor. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.949 |
ETS1 | TBX21 | ENSMMUP00000027254 | ENSMMUP00000062682 | ETS proto-oncogene 1, transcription factor. | T-box transcription factor 21. | 0.539 |
FOXP3 | CBFB | ENSMMUP00000011310 | ENSMMUP00000070667 | Forkhead box P3. | Core-binding factor subunit beta isoform 1. | 0.558 |
FOXP3 | HDAC1 | ENSMMUP00000011310 | ENSMMUP00000013015 | Forkhead box P3. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.585 |
FOXP3 | HDAC2 | ENSMMUP00000011310 | ENSMMUP00000057724 | Forkhead box P3. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.440 |
FOXP3 | RUNX1 | ENSMMUP00000011310 | ENSMMUP00000075631 | Forkhead box P3. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.979 |
FOXP3 | TBX21 | ENSMMUP00000011310 | ENSMMUP00000062682 | Forkhead box P3. | T-box transcription factor 21. | 0.730 |
HDAC1 | FOXP3 | ENSMMUP00000013015 | ENSMMUP00000011310 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Forkhead box P3. | 0.585 |
HDAC1 | HDAC2 | ENSMMUP00000013015 | ENSMMUP00000057724 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.999 |
HDAC1 | MECOM | ENSMMUP00000013015 | ENSMMUP00000002997 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | MDS1 and EVI1 complex locus. | 0.933 |
HDAC1 | RUNX1 | ENSMMUP00000013015 | ENSMMUP00000075631 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.981 |
HDAC1 | RUNX1T1 | ENSMMUP00000013015 | ENSMMUP00000009560 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | RUNX1 partner transcriptional co-repressor 1. | 0.583 |
HDAC2 | FOXP3 | ENSMMUP00000057724 | ENSMMUP00000011310 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Forkhead box P3. | 0.440 |