STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C5AR1Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (349 aa)    
Predicted Functional Partners:
C5
Complement c5 isoform x1; Complement C5
    
 0.981
TLR4
Toll-like receptor 4 precursor; Macaca mulatta toll-like receptor 4 (TLR4), mRNA
   
 
 0.877
TLR2
Toll-like receptor 2 precursor; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and s [...]
   
 
 0.847
ITGB2
Integrin beta-2 isoform x1; Integrin beta
   
 
 0.823
C3
Complement component 3; Complement C3
   
 0.760
ENSMMUP00000031926
Uncharacterized protein
   
 0.760
RPS19
Small subunit ribosomal protein s19e; Ribosomal protein S19
    
 
 0.737
ENSMMUP00000026415
Complement c3 isoform x1; Uncharacterized protein
   
 0.732
C1QC
Complement C1q subcomponent subunit C
   
  
 0.731
CD93
CD93 molecule; Complement component C1q receptor; Uncharacterized protein
   
 
 0.657
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.