STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FBXL5F-box and leucine rich repeat protein 5. (765 aa)    
Predicted Functional Partners:
IREB2
Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family.
    
 0.980
SKP1-2
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.975
CUL1
Cullin 1; Belongs to the cullin family.
    
 0.967
ACO1
Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family.
    
 0.897
CIAO2B
Cytosolic iron-sulfur assembly component 2B.
    
 
 0.837
CUL3
Cullin-3; Belongs to the cullin family.
    
 0.792
ACO2
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
    
 0.732
MMS19
MMS19 homolog, cytosolic iron-sulfur assembly component.
    
 
 0.727
CACUL1
CDK2 associated cullin domain 1; Belongs to the cullin family.
    
 0.680
CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation; Belongs to the WD repeat CIA1 family.
    
 
 0.669
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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