STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PITRM1Pitrilysin metallopeptidase 1. (1037 aa)    
Predicted Functional Partners:
APP
Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]
    
 
 0.824
MIPEP
Mitochondrial intermediate peptidase.
    
 
 0.730
FXN
Frataxin, mitochondrial isoform 1 preproprotein.
     
 0.614
UQCRC1
Ubiquinol-cytochrome c reductase core protein 1.
   
 
 0.613
EPRS1
Glutamyl-prolyl-tRNA synthetase.
  
  
 0.605
COMTD1
Catechol-O-methyltransferase domain containing 1.
     
 0.602
LYRM7
Uncharacterized protein; Belongs to the complex I LYR family.
   
  
 0.595
METAP1
Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
   
 
 0.587
TMEM11
Transmembrane protein 11, mitochondrial.
   
  
 0.582
MRPL42
Mitochondrial ribosomal protein L42.
      
 0.580
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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