node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSPANP00000037075 | MET | ENSPANP00000037075 | ENSPANP00000030652 | Uncharacterized protein. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.565 |
ENSPANP00000037075 | PLAU | ENSPANP00000037075 | ENSPANP00000020280 | Uncharacterized protein. | Plasminogen activator, urokinase. | 0.652 |
ENSPANP00000037075 | PLAUR | ENSPANP00000037075 | ENSPANP00000009949 | Uncharacterized protein. | Plasminogen activator, urokinase receptor. | 0.678 |
ENSPANP00000037075 | SERPINB2 | ENSPANP00000037075 | ENSPANP00000004441 | Uncharacterized protein. | Serpin peptidase inhibitor, clade B, member 2 (Predicted); Belongs to the serpin family. | 0.555 |
ENSPANP00000037075 | SERPINE1 | ENSPANP00000037075 | ENSPANP00000021937 | Uncharacterized protein. | Serpin family E member 1; Belongs to the serpin family. | 0.534 |
ENSPANP00000037075 | SERPINF2 | ENSPANP00000037075 | ENSPANP00000019482 | Uncharacterized protein. | Serpin family F member 2; Belongs to the serpin family. | 0.888 |
ENSPANP00000037075 | VTN | ENSPANP00000037075 | ENSPANP00000019813 | Uncharacterized protein. | SMB domain-containing protein. | 0.591 |
MET | ENSPANP00000037075 | ENSPANP00000030652 | ENSPANP00000037075 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Uncharacterized protein. | 0.565 |
MET | PDGFD | ENSPANP00000030652 | ENSPANP00000005336 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Platelet derived growth factor D. | 0.781 |
MET | PLAU | ENSPANP00000030652 | ENSPANP00000020280 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Plasminogen activator, urokinase. | 0.681 |
MET | PLG | ENSPANP00000030652 | ENSPANP00000018664 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.565 |
PDGFD | MET | ENSPANP00000005336 | ENSPANP00000030652 | Platelet derived growth factor D. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.781 |
PDGFD | PLAU | ENSPANP00000005336 | ENSPANP00000020280 | Platelet derived growth factor D. | Plasminogen activator, urokinase. | 0.731 |
PDGFD | PLG | ENSPANP00000005336 | ENSPANP00000018664 | Platelet derived growth factor D. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.646 |
PLAU | ENSPANP00000037075 | ENSPANP00000020280 | ENSPANP00000037075 | Plasminogen activator, urokinase. | Uncharacterized protein. | 0.652 |
PLAU | MET | ENSPANP00000020280 | ENSPANP00000030652 | Plasminogen activator, urokinase. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.681 |
PLAU | PDGFD | ENSPANP00000020280 | ENSPANP00000005336 | Plasminogen activator, urokinase. | Platelet derived growth factor D. | 0.731 |
PLAU | PLAUR | ENSPANP00000020280 | ENSPANP00000009949 | Plasminogen activator, urokinase. | Plasminogen activator, urokinase receptor. | 0.996 |
PLAU | PLG | ENSPANP00000020280 | ENSPANP00000018664 | Plasminogen activator, urokinase. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.942 |
PLAU | SERPINB2 | ENSPANP00000020280 | ENSPANP00000004441 | Plasminogen activator, urokinase. | Serpin peptidase inhibitor, clade B, member 2 (Predicted); Belongs to the serpin family. | 0.760 |