node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
G3QHL6_GORGO | G3RID2_GORGO | ENSGGOP00000001846 | ENSGGOP00000015431 | Interleukin 1 receptor associated kinase 2. | TIR domain-containing protein. | 0.644 |
G3QHL6_GORGO | IKBKG | ENSGGOP00000001846 | ENSGGOP00000004800 | Interleukin 1 receptor associated kinase 2. | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.748 |
G3QHL6_GORGO | IL1R1 | ENSGGOP00000001846 | ENSGGOP00000003288 | Interleukin 1 receptor associated kinase 2. | Interleukin 1 receptor type 1. | 0.839 |
G3QHL6_GORGO | IRAK1 | ENSGGOP00000001846 | ENSGGOP00000018313 | Interleukin 1 receptor associated kinase 2. | Interleukin 1 receptor associated kinase 1. | 0.930 |
G3QHL6_GORGO | IRAK4 | ENSGGOP00000001846 | ENSGGOP00000020959 | Interleukin 1 receptor associated kinase 2. | Interleukin 1 receptor associated kinase 4. | 0.973 |
G3QHL6_GORGO | MAP3K7 | ENSGGOP00000001846 | ENSGGOP00000020634 | Interleukin 1 receptor associated kinase 2. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.685 |
G3QHL6_GORGO | MYD88 | ENSGGOP00000001846 | ENSGGOP00000003761 | Interleukin 1 receptor associated kinase 2. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.997 |
G3QHL6_GORGO | TIRAP | ENSGGOP00000001846 | ENSGGOP00000018948 | Interleukin 1 receptor associated kinase 2. | TIR domain containing adaptor protein. | 0.810 |
G3QHL6_GORGO | TLR7 | ENSGGOP00000001846 | ENSGGOP00000020624 | Interleukin 1 receptor associated kinase 2. | Toll like receptor 7; Belongs to the Toll-like receptor family. | 0.697 |
G3QHL6_GORGO | TRAF6 | ENSGGOP00000001846 | ENSGGOP00000005734 | Interleukin 1 receptor associated kinase 2. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.998 |
G3RID2_GORGO | G3QHL6_GORGO | ENSGGOP00000015431 | ENSGGOP00000001846 | TIR domain-containing protein. | Interleukin 1 receptor associated kinase 2. | 0.644 |
G3RID2_GORGO | IKBKG | ENSGGOP00000015431 | ENSGGOP00000004800 | TIR domain-containing protein. | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | 0.441 |
G3RID2_GORGO | IL1R1 | ENSGGOP00000015431 | ENSGGOP00000003288 | TIR domain-containing protein. | Interleukin 1 receptor type 1. | 0.609 |
G3RID2_GORGO | IRAK1 | ENSGGOP00000015431 | ENSGGOP00000018313 | TIR domain-containing protein. | Interleukin 1 receptor associated kinase 1. | 0.844 |
G3RID2_GORGO | IRAK4 | ENSGGOP00000015431 | ENSGGOP00000020959 | TIR domain-containing protein. | Interleukin 1 receptor associated kinase 4. | 0.665 |
G3RID2_GORGO | MYD88 | ENSGGOP00000015431 | ENSGGOP00000003761 | TIR domain-containing protein. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.998 |
G3RID2_GORGO | TIRAP | ENSGGOP00000015431 | ENSGGOP00000018948 | TIR domain-containing protein. | TIR domain containing adaptor protein. | 0.971 |
G3RID2_GORGO | TLR7 | ENSGGOP00000015431 | ENSGGOP00000020624 | TIR domain-containing protein. | Toll like receptor 7; Belongs to the Toll-like receptor family. | 0.994 |
G3RID2_GORGO | TRAF6 | ENSGGOP00000015431 | ENSGGOP00000005734 | TIR domain-containing protein. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.794 |
IKBKG | G3QHL6_GORGO | ENSGGOP00000004800 | ENSGGOP00000001846 | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. | Interleukin 1 receptor associated kinase 2. | 0.748 |