TOX3 protein (Gorilla gorilla) - STRING interaction network

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Predicted Interactions

gene neighborhood

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[Homology]

Score

TOX3

TOX high mobility group box family member 3. (576 aa)

Predicted Functional Partners:

SALL1

0.703

SMOC1

0.675

LSP1

0.672

MAP3K1

0.655

BRCA2

0.642

G3QZ51_GORGO

0.629

G3R1K1_GORGO

0.628

RAD51B

0.613

BRCA1

0.596

NEK10

0.592

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	BRCA2	ENSGGOP00000023921	ENSGGOP00000027226	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA2 DNA repair associated.	0.999
BRCA1	G3QZ51_GORGO	ENSGGOP00000023921	ENSGGOP00000008150	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Fibroblast growth factor receptor.	0.470
BRCA1	LSP1	ENSGGOP00000023921	ENSGGOP00000002399	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Lymphocyte specific protein 1.	0.483
BRCA1	MAP3K1	ENSGGOP00000023921	ENSGGOP00000014248	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Mitogen-activated protein kinase kinase kinase 1.	0.585
BRCA1	RAD51B	ENSGGOP00000023921	ENSGGOP00000048047	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Uncharacterized protein.	0.807
BRCA1	TOX3	ENSGGOP00000023921	ENSGGOP00000008909	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	TOX high mobility group box family member 3.	0.596
BRCA2	BRCA1	ENSGGOP00000027226	ENSGGOP00000023921	BRCA2 DNA repair associated.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BRCA2	G3QZ51_GORGO	ENSGGOP00000027226	ENSGGOP00000008150	BRCA2 DNA repair associated.	Fibroblast growth factor receptor.	0.442
BRCA2	LSP1	ENSGGOP00000027226	ENSGGOP00000002399	BRCA2 DNA repair associated.	Lymphocyte specific protein 1.	0.529
BRCA2	MAP3K1	ENSGGOP00000027226	ENSGGOP00000014248	BRCA2 DNA repair associated.	Mitogen-activated protein kinase kinase kinase 1.	0.481
BRCA2	RAD51B	ENSGGOP00000027226	ENSGGOP00000048047	BRCA2 DNA repair associated.	Uncharacterized protein.	0.941
BRCA2	TOX3	ENSGGOP00000027226	ENSGGOP00000008909	BRCA2 DNA repair associated.	TOX high mobility group box family member 3.	0.642
G3QZ51_GORGO	BRCA1	ENSGGOP00000008150	ENSGGOP00000023921	Fibroblast growth factor receptor.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.470
G3QZ51_GORGO	BRCA2	ENSGGOP00000008150	ENSGGOP00000027226	Fibroblast growth factor receptor.	BRCA2 DNA repair associated.	0.442
G3QZ51_GORGO	LSP1	ENSGGOP00000008150	ENSGGOP00000002399	Fibroblast growth factor receptor.	Lymphocyte specific protein 1.	0.448
G3QZ51_GORGO	TOX3	ENSGGOP00000008150	ENSGGOP00000008909	Fibroblast growth factor receptor.	TOX high mobility group box family member 3.	0.629
G3R1K1_GORGO	SALL1	ENSGGOP00000009078	ENSGGOP00000000651	Ephrin A1; Belongs to the ephrin family.	Spalt like transcription factor 1.	0.648
G3R1K1_GORGO	SMOC1	ENSGGOP00000009078	ENSGGOP00000024452	Ephrin A1; Belongs to the ephrin family.	SPARC related modular calcium binding 1.	0.639
G3R1K1_GORGO	TOX3	ENSGGOP00000009078	ENSGGOP00000008909	Ephrin A1; Belongs to the ephrin family.	TOX high mobility group box family member 3.	0.628
LSP1	BRCA1	ENSGGOP00000002399	ENSGGOP00000023921	Lymphocyte specific protein 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.483