STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (405 aa)    
Predicted Functional Partners:
HSD11B1
Hydroxysteroid 11-beta dehydrogenase 1.
   
 
0.990
AKR1D1
Aldo-keto reductase family 1 member D1.
   
 
 0.957
CYP21A2
Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family.
   
 
 0.956
G3QLD6_GORGO
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.
   
 
 0.942
HSD3B2
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family.
   
 
 0.924
H6PD
Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.
   
  
 0.699
ENSGGOP00000049589
Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.
   
  
 0.696
NR3C2
Nuclear receptor subfamily 3 group C member 2.
   
 
 0.690
G3QLK2_GORGO
LDL receptor related protein associated protein 1.
      
 0.686
G3QUH6_GORGO
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
   
  
 0.673
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.